Aripiprazole is a new antipsychotic drug used in schizophrenia. It acts on serotonin 5-HT2A receptors. Drug undergoes extensive first pass metabolism. Oral dose was practically insoluble in water and sparingly soluble in 0.1 N HCl. In psychotic patients, unpredictable symptoms are observed any time mainly in schizophrenia, Parkinson’s disease and migraine. Thus, it requires immediate action to minimize the symptoms. Moreover, patients are also not in condition to take dosage form by themselves and have difficulty in swallowing. Gelucire 44/14 was used as a carrier for improving solubility of aripiprazole by melt granulation technique. Different ratio of drug to gelucire were tried and depending upon DSC, FTIR and solubility studies 1:2 ratio of aripiprazole to gelucire was considered as significant proportion. Optimized ratio was used to prepared oral dispersible tablet using calcium silicate (FM1000) as dispersing agent and orocell and MCC burst as novel diluent. Prepared tablets were evaluated for various parameters like disintegration, dissolution study, hardness, friability etc. optimized batch showed friability 0.4±0.04, hardness 3±0.2 kg/cm2, wetting time 28±3 sec and disintegration time 32±3 sec. Thus, optimized tablet was sufficiently capable of delivering rapid drug release of such practically insoluble drug using novel excipients.
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